There are number of state abbreviations in the 1800s, which confuse modern collectors familiar only with today's 2-letter abbrevations. Indiana is "IA" and Massachusetts is "MS" on many stampless covers. Nebraska used both NE and NB as recently as 50-60 years ago, etc.
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SEP / 17 is slightly tilted clockwise.
There are various designs/constructions to these cancel devices, but they are all fairly easy and quick to change the internal time/date slugs. Some of them have a handle which screws-off and the slugs are inserted from behind, then the handle screwed back on. As a pure guess, I suspect the tilt may reflect such a construction and some screw-on front or back part was not tightened all the way, which would have fully alighned the internal time/date slugs with no tilt.