Collecting And Mounting Se-Tenant Stamps

I have a question that is likely to prompt as many answers as there are collectors, but here it goes.

I understand the concept of se-tenant stamps, triptychs, etc., when multiple stamps make up one complete design and they are rightly collected in order of their complete design and mounted in a stamp album or stockbook that way.

However, when you get into se-tenant stamps that have no direct relationship with the stamps next to them, is there any reason why they should be collected as se-tenant? In almost all instances they are modern issues that are unlikely to appreciate that significantly in value and the cost to supply mounts large enough to attach the entire strip or block multiples to an album page just doesn't seem worth it, especially when collectors complain that they dislike the way some stamp albums that lay them out (i.e. diagonally). It seems to me that in these cases, I could easily create my own album page for an issue of 8 or 10 stamps and insert it into my own album, separating the stamps but keeping the "collection" of them complete by mounting them either as as singles or in pairs or blocks to make a more balanced appearance on an album page.

Also, when it comes to se-tenant stamps that have no direct design relationship to each other (i.e. Lady Liberty and Flag stamp, for example) is there any reason they should be collected se-tenant with one stamp before or after the other or maybe it doesn't really matter.

I realize that due to space limitations catalogs can only list these stamps one way, but if one chooses to collect them in the alternate pair (i.e. Flag and Lady Liberty v. Lady Liberty and Flag) is there any reason not to do it that way. In other words, would there be any diminished value in collecting them in that way?

I know the old adage about there being "no rules" in stamp collecting and you should simply collect stamps the way that best pleases you, but I'm just curious what other collectors think about such an arrangement, especially when mounting the stamps in an album.