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In my eyes it is better to buy at the beginning of such an event, than at the end, because the best pieces in such a box will not stay long there!
I agree and that is one reason why I also hit the boxes early. The point I am trying to make is that many dealers are willing to consider an offer, even early in a show. After over 50 years of attending stamp shows, though, I have found that a dealer tends to be more receptive to an offer towards the end of a show than the beginning.
If I am turned down on an offer and willing to pay what the dealer wants for them, then I will buy them. If I really want the items I do not wait to see if they are still available later.