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You guessed it - rotary vs. flat plate printing, which by tradition, "requires" a symmetrical (6) plate block.
Although that is the generally accepted reason for the change from plate blocks of 6 to 4, there are some exceptions.
For example, some early stamps had more selvage markings such as arrows, stars or multiple plate numbers (on bi-colored stamps) that required 6 or even 8 stamps to make up a collectible plate block.
Then you fast forward to the 1960s when multiple colors and plate numbers were used and you had to collect 6, 8, 10, 12 ... up to 20 stamps to make a complete plate block (or plate strip, as the term came into use).
With today's self adhesives and with multiple images being part of the same issue, nothing less than a full pane of stamps will typically do since a representative example of each face different stamp from that issue is typically required.
This is part of the very reason why plate block collecting has lost favor with many modern day collectors.