If it's of any help, as it relates to the second cover addressed to a Samuel Creaghead, Cincinnati, Ohio, I note that the US Census lists him and his family in 1860 as residing in Covington, KY (very near Cincinnati) and his occupation listed as "real estate agent". Samuel (age 40), and his wife, Sue (age 30) had three children. (It's possible his residence could have been in Covington, KY and his business office in Cincinnati, OH).
In fact, Samuel Creaghead died on July 11, 1883 and is buried in Covington. His gravestone suggests he lived from 1820-1883:
http://www.findagrave.com/cgi-bin/f...Rid=89673090