I thought it was interesting to note that "On This Day in History" -- February 10th -- the first Highway Post Office was inaugurated in 1941 as shown by this image of a cover released for the first run going between Harrisonburg, VA and Washington, DC:

Of course, HPO's didn't "take off" until after World War I, as this "retro video" points out:
http://www.postalmuseum.si.edu/exhi...movie.html#1Still, I wonder how many collectors have Highway Post Office cancels and covers. Surprisingly, many of the "First Trip" covers can be had for less than $1, so although it seems they are quite common, they are nevertheless a part of US Postal History.