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1. Can the tagging disappear completely from a US stamp is soaked/treated?
Yes, on the earlier stamps in which the taggant was applied after the printing (i.e., not pre-phosphored), it can happen that tagging can be completely removed by oversoaking in warm water that is not very pure (e.g., contains dilute bleaching agents). It's not guaranteed, but it does happen. Off cover used tagging omitted errors are difficult to prove. On cover is better, mint is definitely preferred. On cover examples are typically hand or pen cancelled or completely uncancelled because they got kicked out of the sorting machinery. If I remember correctly, that's how the 19c fishboat untagged (relatively common) was discovered.
I've got a few used "almost completely missing" tagging examples, but you can see a few glowing specs under filtered higher wattage UV. I think I've only been able to find about 2 examples used where I cannot see any glow -- but as I mentioned, it's really hard to be assured.
I've noticed that on examples with tagging mostly missing, the paper often glows unevenly on one or more sides under longwave UV excitation, or does not match the glow of known paper varieties -- suggesting that the paper surface has had some chemical interactions. At least one of my "no trace" used stamps also has uneven paper glow and the paper does not appear "fresh", so I pretty much assume that is not a genuine tagging omitted error.
Obviously, tagging omitted errors are a lot easier to confirm on mint stamps. They really are not that common for most stamps (a few exceptions). But the demand is quite low so the catalog values will never reflect true scarcity.