The difference is in the watermark. Watermarks are applied to stamp paper before printing to discourage counterfeiting. You can see the watermark by placing the stamp in a dark tray and immersing it in commercially available watermark detection fluid.
Both are 50 pfennig stamps showing German President von Hindenburg.
Scott 411 was issued in 1933 on paper with watermark type 126, which has a fishnet pattern:

Scott 428 was issued in 1934 on paper with watermark type 237, which has a pattern of Nazi swastikas:

So the political changes in Germany in the early 1930s are evident in the changes in the watermarks.