Generally referred to as "blind perforations or perfs" they
almost alwaysreduce the value of the stamp(s)
except in some cases that involve small segments or categories of collecting as pointed out by Bart belowand in the case of pricier items is likely the reason they are on
ebay or similar venues as opposed to a regular auction house/dealer. For common items there really is no reason to purchase these over the same item with nice perforations since there are many fish in the sea.
Note: Edited to reflect Bart's two cents