All of the magenta and manuscript markings on the the front appear to be non-postal in origin, but rather applied by the receiving company.
The New York Institute of Science being ....


From Arthur J. Cramp, ed. "Nostrums and Quackery", published by the American Medical Assn, 1921, vol II, pages 305-6 shown here and the discussion runs on to page 314, but too much to scan/post here