So I'm finally just sitting down to look at the cover on a real computer. I've been out of pocket all weekend until just now. Identifying a 46L12 late at night on the iPhone was interesting.
My first reaction when I first saw the cover was that it was weird as heck, but perfectly legit.
Ok, first comment - I love the 71L1L left margin, Winston. The invert is there, and is awesome !!
I used to really search for inverts with big left margins. Very nice.
The Dubuque cancel is listed and correct for 1861 in the ASCC. No problem there.
For the record, it is a double circle cancel, and not a duplex cancel. A duplex is a combined CDS + killer. This is just a double-circle CDS. Nevertheless, this DC CDS is only known in 1861.
The comments on the board about there is no 1851 year-dated cancel are absolutely correct. Of course, I'm ignoring the well-known Sonora, CA straight lines and a very few others. For normal CDS's -- they simply don't exist with 1851 year dates. So, I won't argue that there is a strong resemblance to a 5 here, but it simply isn't. Whether its cancel distortion at work here, or an odd 'font/serif' that was used for the 6, the fact remains that it is a 6, regardless of what your eyes tell you. This truly is something you just have to get some background with to fully appreciate. You'll just have to take our word for it.

I was initially worried about the lower left stamp placement together with what looked like water damage -- which is always a red flag of potential stamp-replacement, but now that I can actually see the cover on a big screen, I realize that it is gum-soak, which likely happened when the stamps were applied and probably smeared a bit until they found a sticking place. That's fine.
With regard to late, out of period usages, there are always some wacko cases, this being one. I've seen a pair of #9's used in the mid 1860s obliterated by a real duplex cancel. Looked weird as heck also, but I couldn't find fault with it, at least from just the picture I saw. Stuff happens.
It is true that I've seen quite a few #24s mixed with #9s or #7s on cover for mixed usages. Those are neat, and findable. I don't off-hand recall seeing a Plate 11 or Plate 12 stamp used with a #9. Those plates are mostly if not exclusively 1861 plates so its a rare find. Obviously not impossible.
My take on this cover is its totally awesome. I agree totally with Winston, that its like Baskin Robbins. Very apropos title for this thread. This cover definitely has 31 (or more) terrific flavors to it, depending on what you want to collect on a given day!